t(14;14)(q11;q32) in biphenotypic blastic phase of chronic myeloid leukemia
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چکیده
منابع مشابه
Differentiation patterns in the blastic phase of chronic myeloid leukemia.
The surface antigen phenotype of 30 patients with the blast phase of chronic myeloid leukemia (CML) was determined using a panel of monoclonal antibodies recognizing differentiation antigens of normal myeloid, erythroid, megakaryocyte, and lymphoid cells. Ten patients' cells expressed a phenotype corresponding to an immature myeloid cell and were felt to have "myeloid" blast crisis. None of the...
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The BCR-ABL1 oncoprotein transforms pluripotent HSCs and initiates chronic myeloid leukemia (CML). Patients with early phase (also known as chronic phase [CP]) disease usually respond to treatment with ABL tyrosine kinase inhibitors (TKIs), although some patients who respond initially later become resistant. In most patients, TKIs reduce the leukemia cell load substantially, but the cells from ...
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For present work, 27 clinically diagnosed Chronic Myeloid Leukemia patients were selected, who attended the Out Patient Department of Gujarat Cancer and Research Institute, Ahmedabad. In all these cases relevant history, clinical findings, haematological data and other investigations were noted & bone-marrow samples were obtained for further study, which was done at Genetics Laboratory, B.J. Me...
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Figure 1. Leukemic cell morphology of bone marrow aspiration specimen (May-Grünwald-Giemsa). An 82-year-old woman was admitted to our hospital presenting with febrile neutropenia. She had been diagnosed with chronic myeloid leukemia 2 years ago and had been on imatinib treatment since [1]. A month before admission she presented with malaise, anemia, and mild leukopenia; a bone marrow aspirate a...
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4. Kikutani H, Inui S, Sato R, Barsumian E, Owaki H, Yamasaki Y, Kaisho T, Uchibayashi N, Hardy R, Hirano T, Tsunasawa 5, Sakiyama F, Svemura M, Kishimoto T: Molecular structure of human lymphocyte receptor for immunoglobulin E. Cell 47:657, 1986 5. Ikuta K, Takami M, Kim CW, Honjo T, Miyoshi T, Tagaya Y, Kawabe T, Yodoi J: Human Lymphocyte Fc receptor for IgE: Sequence homology of its cloned c...
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ژورنال
عنوان ژورنال: Blood
سال: 1986
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v68.4.949.bloodjournal684949